NGEF anticorps

N° du produit ABIN7252975

Cet anticorps anti-NGEF est un anticorps Lapin Polyclonal détectant NGEF dans WB, ELISA et IHC. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour NGEF anticorps (ABIN7252975)

Antigène: NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NGEF est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-NGEF anticorps

Attributs du produit: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogène: Fusion protein of human NGEF

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.6 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur NGEF

Antigène: NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))

Autre désignation: NGEF

Sujet: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).

Poids moléculaire:

Observed_MW: Refer to figures

Calculated_MW: 82 kDa

UniProt: Q8N5V2

Pathways: Neurotrophin Signaling Pathway