ATR anticorps

N° du produit ABIN7254349

L’anticorps Lapin Polyclonal anti-ATR a été validé pour ELISA et IHC. Il convient pour détecter ATR dans des échantillons de Humain.

Aperçu rapide pour ATR anticorps (ABIN7254349)

Antigène: ATR (ATR serine/threonine kinase (ATR))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATR est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-ATR anticorps

Attributs du produit: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogène: Synthetic peptide of human ATR

Isotype: IgG

Information d'application

Indications d'application: IHC 1:40-1:200, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.1 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur ATR

Antigène: ATR (ATR serine/threonine kinase (ATR))

Autre désignation: ATR

Sujet: The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.

UniProt: Q13535

Pathways: Positive Regulation of Response to DNA Damage Stimulus