SFPQ anticorps

N° du produit ABIN7255047

L’anticorps Lapin Polyclonal anti-SFPQ a été validé pour WB, IHC et IF. Il convient pour détecter SFPQ dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour SFPQ anticorps (ABIN7255047)

Antigène: SFPQ (Splicing Factor Proline/glutamine-Ric (SFPQ))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SFPQ est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-SFPQ anticorps

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human SFPQ (NP_005057.1).

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000 IHC 1:50-1:100 IF 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur SFPQ

Antigène: SFPQ (Splicing Factor Proline/glutamine-Ric (SFPQ))

Autre désignation: SFPQ

Sujet: DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells, T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A.

Poids moléculaire:

Observed_MW: 115 kDa

Calculated_MW: 72 kDa/76 kDa

ID gène: 6421

UniProt: P23246