TERT anticorps

N° du produit ABIN7259294

Cet anticorps Lapin Polyclonal détecte spécifiquement TERT dans IHC. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour TERT anticorps (ABIN7259294)

Antigène: TERT (Telomerase Reverse Transcriptase (TERT))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TERT est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-TERT anticorps

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: A synthetic peptide of human TERT (NP_937983.2).

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur TERT

Antigène: TERT (Telomerase Reverse Transcriptase (TERT))

Autre désignation: TERT

Sujet: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified, the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.

ID gène: 7015

UniProt: O14746

Pathways: Telomere Maintenance