SMC1A anticorps (pSer957)

N° du produit ABIN7265084

Cet anticorps anti-SMC1A est un anticorps Lapin Polyclonal détectant SMC1A dans WB et IF. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour SMC1A anticorps (pSer957) (ABIN7265084)

Antigène: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMC1A est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-SMC1A anticorps

Épitope: pSer957

Attributs du produit: Phosphorylated antibody

Purification: Affinity purification

Immunogène: A synthetic phosphorylated peptide around S957 of human SMC1A (NP_006297.2).

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000 IF 1:20-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur SMC1A

Antigène: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Autre désignation: SMC1A

Sujet: Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Poids moléculaire:

Observed_MW: 160 kDa

Calculated_MW: 143 kDa

ID gène: 8243

UniProt: Q14683

Pathways: Stem Cell Maintenance