TLN1 anticorps (AA 1601-1750)

N° du produit ABIN701695

Cet anticorps Lapin Polyclonal détecte spécifiquement TLN1 dans ELISA, IHC (p), IHC (fro), IF (cc) et IF (p). Il présente une réactivité envers Souris et Rat et a été mentionné dans 2+ publications.

Aperçu rapide pour TLN1 anticorps (AA 1601-1750) (ABIN701695)

Antigène: TLN1 (Talin 1 (TLN1))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TLN1 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-TLN1 anticorps

Épitope: AA 1601-1750

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Talin 1.

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-TLN1 (ABIN701695)

He, Meng, Yao, Jiang, Wu, Wu: "The essential role of inorganic substrate in the migration and osteoblastic differentiation of mesenchymal stem cells." dans: Journal of the mechanical behavior of biomedical materials, Vol. 59, pp. 353-65, (2016) (PubMed).

Dingyu, Fanjie, Zhengzheng, Baosheng, Chao, Yi, Huiwen, Jun, Gang: "Regulation of Intracellular Structural Tension by Talin in the Axon Growth and Regeneration." dans: Molecular neurobiology, (2015) (PubMed).

Détails sur TLN1

Antigène: TLN1 (Talin 1 (TLN1))

Autre désignation: Talin1

Sujet:

Synonyms: TLN 1, ILWEQ, Talin 1, Talin, TLN, TLN1, TLN 2, Talin 2, Talin 2, TLN2.

Background: Talin, a multifunctional constituent of cell-substratum attachment sites, is a high molecular weight protein (225-270 kDa) found in variety of tissues and cell types. It is localized at a subset of adherens junctions, specialized cell-cell and cell-matrix associations that are characterized by the presence of filamentous actin at the cytoplasmic face of the junctional complex. In cultured cells, talin is absent from cell-cell junctions and found predominantly at adhesion plaques and in fibrillar streaks underlying cell surface fibronectin. Talin interacts with at least two other proteins that are localized at adhesion plaques, vinculin and integrin. Talin and vinculin have been shown to interact with each other and both have been proposed to be involved in generating the transmembrane connection, between the extracellular matrix and the cytoskeleton, that occurs at adhesion plaques. At physiological ionic strength, talin is an elongate, flexible, monomeric protein with the ability to self-associate into dimers at higher protein concentrations.

ID gène: 7094, 83660

UniProt: Q9Y4G6, Q9Y490

Pathways: Cell-Cell Junction Organization, ER-Nucleus Signaling, Maintenance of Protein Location