KEAP1 anticorps (AA 65-160)

N° du produit ABIN702085

Cet anticorps Lapin Polyclonal détecte spécifiquement KEAP1 dans WB, ELISA, IHC (p), IF (cc), IF (p) et IHC (fro). Il présente une réactivité envers Humain, Souris, Rat, Porc et Lapin et a été mentionné dans 5+ publications.

Aperçu rapide pour KEAP1 anticorps (AA 65-160) (ABIN702085)

Antigène: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Reactivité: Humain, Souris, Rat, Porc, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KEAP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-KEAP1 anticorps

Épitope: AA 65-160

Réactivité croisée: Humain, Souris, Porc, Lapin, Rat

Homologie: Dog,Cow

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human KEAP1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-KEAP1 (ABIN702085)

Su, Liu, Wang, Wang, Song, Song: "The electrophilic character of quinones is essential for the suppression of Bach1." dans: Toxicology, Vol. 387, pp. 17-26, (2017) (PubMed).

Kouam, Yuan, Njayou, He, Tsayem, Oladejo, Song, Moundipa, Gao: "Induction of Mkp-1 and Nuclear Translocation of Nrf2 by Limonoids from Khaya grandifoliola C.DC Protect L-02 Hepatocytes against Acetaminophen-Induced Hepatotoxicity." dans: Frontiers in pharmacology, Vol. 8, pp. 653, (2017) (PubMed).

Chen, Lin, Liu, Hsu, Lin, Su: "Caveolin-1 Expression Ameliorates Nephrotic Damage in a Rabbit Model of Cholesterol-Induced Hypercholesterolemia." dans: PLoS ONE, Vol. 11, Issue 4, pp. e0154210, (2016) (PubMed).

Su, Zhang, Song, Shi, Fu, Xia, Bai, Hu, Xu, Song, Song: "Tetrachlorobenzoquinone activates nrf2 signaling by keap1 cross-linking and ubiquitin translocation but not keap1-cullin3 complex dissociation." dans: Chemical research in toxicology, Vol. 28, Issue 4, pp. 765-74, (2015) (PubMed).

Su, Xia, Shi, Song, Fu, Xiao, Chen, Lu, Sun, Wu, Yang, Li, Ye, Song, Song: "Neohesperidin Dihydrochalcone versus CCl?-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation." dans: Journal of agricultural and food chemistry, Vol. 63, Issue 22, pp. 5468-75, (2015) (PubMed).

Détails sur KEAP1

Antigène: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Autre désignation: KEAP1

Sujet:

Synonyms: INrf2, KLHL19, Kelch-like ECH-associated protein 1, Cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, KIAA0132

Background: Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.

ID gène: 9817

UniProt: Q14145

Pathways: Maintenance of Protein Location