DRD5 anticorps (2nd Extracellular Loop)

N° du produit ABIN7043111

L’anticorps anti-DRD5 Polyclonal Lapin est utilisé pour la détection de DRD5 dans des échantillons de Rat. Il a été validé pour WB, IHC, FACS, IF et LCI.

Aperçu rapide pour DRD5 anticorps (2nd Extracellular Loop) (ABIN7043111)

Antigène: DRD5 (Dopamine Receptor D5 (DRD5))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DRD5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Live Cell Imaging (LCI)

Détail du produit anti-DRD5 anticorps

Épitope: 2nd Extracellular Loop, AA 199-211

Fonction: A Rabbit Polyclonal Antibody to D5 Dopamine Receptor

Réactivité croisée: Souris, Rat

Réactivité croisée (Details): Unlikely to recognize human samples.

Homologie: Mouse - 12,13 amino acid residues identical

Attributs du produit: Anti-D5 Dopamine Receptor (extracellular) Antibody is directed against an epitope located at the 2nd extracellular loop of the rat D5 dopamine receptor. Anti-D5 Dopamine Receptor (extracellular) Antibody (ABIN7043111, ABIN7044234 and ABIN7044235) can be used in western blot analysis and immunohistochemical applications, and recognizes DRD5 from rat and mouse samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: EEGWELEGRTENC, corresponding to amino acid residues 199-211 of rat DRD5 

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:100

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235250)

Blocking Peptide: (ABIN7235250)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur DRD5

Antigène: DRD5 (Dopamine Receptor D5 (DRD5))

Autre désignation: DRD5

Sujet:

Synonyms: DRD5, D(1B) dopamine receptor

Description: The D5 dopamine receptor (D5 receptor) is one of five receptors that mediate the effects of the catecholamine neurotransmitter dopamine. Dopamine regulates a variety of functions including locomotor activity, emotion, positive reinforcement, food intake, and hormone secretion. The dopaminergic system has been extensively studied in the last thirty years mainly because its dysregulation has been linked to several neurological and neuropsychiatric diseases including Parkinson's disease and Schizophrenia.1All five dopamine receptors belong to the 7-transmembrane domain, G-protein coupled receptor (GPCR) superfamily.Historically, the five receptors have been divided into two subfamilies based on pharmacological and structural considerations: the D1-like subfamily (that includes the D1 and D5 subtypes) and the D2-like subfamily (that includes the D2-, D3- and D4 subtypes).1 The D1-like receptors are coupled to Gs-type G proteins and enhance adenylate cyclase activity while the D2-like receptors are coupled to Gi-type G proteins and inhibit adenylate cyclase activity.1The D5 receptor is widely distributed throughout the brain with the highest expression in the cerebral cortex, hippocampus and striatum. In the periphery, the D5 receptor has been localized in the adrenal cortex, kidney and intestinal tract.The exact physiological function of the D5 receptor subtype remains poorly understood. Studies with D5 receptor knockout mice have shown no overt alterations in locomotor or cognitive functions. However, knockout mice do develop severe hypertension suggesting a role of the D5 receptor in the modulation of neuronal pathways regulating blood pressure responses.2,3

ID gène: 25195

NCBI Accession: NM_000798

UniProt: P25115

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity