FZD2 anticorps (Extracellular, N-Term)

N° du produit ABIN7043141

L’anticorps anti-FZD2 Polyclonal Lapin est utilisé pour la détection de FZD2 dans des échantillons de Rat. Il a été validé pour WB, FACS et LCI.

Aperçu rapide pour FZD2 anticorps (Extracellular, N-Term) (ABIN7043141)

Antigène: FZD2 (Frizzled Family Receptor 2 (FZD2))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FZD2 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Détail du produit anti-FZD2 anticorps

Épitope: AA 192-205, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to Frizzled-2

Réactivité croisée: Humain, Rat

Homologie: Human - identical, mouse - 13,14 amino acid residues identical

Attributs du produit: Anti-Frizzled-2 (FZD2) (extracellular) Antibody is directed against an epitope of rat Frizzled-2. Anti-Frizzled-2 (FZD2) (extracellular) Antibody (ABIN7043141, ABIN7044285 and ABIN7044286) can be used in western blot analysis. The antibody recognizes an extracellular epitope and is thus ideal for detecting the receptor in living cells. It has been designed to recognize FZD2 from rat, mouse and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)GAPPRYATLEHPFH, corresponding to amino acid residues 192-205 of rat Frizzled-2

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235341)

Blocking Peptide: (ABIN7235341)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur FZD2

Antigène: FZD2 (Frizzled Family Receptor 2 (FZD2))

Autre désignation: FZD2

Sujet:

Synonyms: Frizzled class receptor 2, Fz-2

Description: Frizzled receptors (FZD) belong to the superfamily of G-protein coupled receptors (GPCR). They are classified to the frizzled subfamily for which 11 members have been identified to date, FZD1-10 and Smoothened1. They were first identified in Drosophila melanogaster.Like all GPCRs, Frizzled receptors have seven transmembrane domains, an extracellular N-terminus and an intracellular C-terminal tail. However, these receptors lack many features of the conventional class A, B or C GPCRs2.Activation of these receptors by WNT, leads to numerous complex signaling pathways which are generally termed β-catenin-dependent and β-catenin-independent. It is noteworthy to mention that the β-catenin-dependent pathway involves the interaction of FZD with LRP6 or LRP5 co-receptors3.Frizzled receptors are ubiquitously expressed and play a crucial role in embryo development. They are also significantly involved in proliferation and differentiation. Indeed, dysregulation of FZD leads to various forms of cancer1. Scientific evidence also shows their involvement in axonal remodeling and neurotransmitter release1.They have been associated to Alzheimer's and Parkinson's diseases, depression, anxiety, hypoxia and ischemia. It is thus not surprising that they have become pharmacological targets in a number of diseases and disorders.

ID gène: 64512

NCBI Accession: NM_001466

UniProt: Q08464

Pathways: Signalisation WNT