GIPC1 anticorps (Intracellular)

N° du produit ABIN7043215

Cet anticorps Lapin Polyclonal détecte spécifiquement GIPC1 dans WB, IHC et IF. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour GIPC1 anticorps (Intracellular) (ABIN7043215)

Antigène: GIPC1 (GIPC PDZ Domain Containing Family, Member 1 (GIPC1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GIPC1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-GIPC1 anticorps

Épitope: AA 10-24, Intracellular

Fonction: A Rabbit Polyclonal Antibody to GIPC1

Specificité: Intracellular, N-terminus

Réactivité croisée: Humain, Souris, Rat

Homologie: Rat,mouse - 14,15 amino acid residues identical

Attributs du produit: Anti-GIPC1 Antibody (ABIN7043215, ABIN7045188 and ABIN7045189) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize GIPC1 from human, rat, and mouse samples.

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)KAPPLVENEEAEPGR, corresponding to amino acid residues 10-24 of human GIPC1

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200

Application Dilutions Western blot wb: 1:400

Commentaires:

Negative Control: (ABIN7235592)

Blocking Peptide: (ABIN7235592)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur GIPC1

Antigène: GIPC1 (GIPC PDZ Domain Containing Family, Member 1 (GIPC1))

Autre désignation: GIPC1

Sujet: PDZ domain-containing protein GIPC1, GIPC, GAIP C-terminus-interacting protein, RGS-GAIP-interacting protein, Synectin, NIP, TIP-2,GIPC1 belongs to a family of evolutionarily conserved adaptor proteins responsible for the trafficking of numerous transmembrane proteins via endocytosis. Members of GIPC (GAIP interacting protein, C-terminus) have three main domains responsible for protein interactions, a PDZ domain which is flanked by GH1 and GH2 domains. GH1 domain is responsible for the dimerization of the protein, while GH2 is important for the interaction of GIPC1 with MYO6, a retrograde motor protein involved in protein trafficking. The PDZ domain of GIPC1 is responsible for the protein to interact with numerous proteins, namely β1-adrenoceptor, D2 dopamine receptor, GLUT1, TrkA receptor just to name a few. The zebrafish ortholog also interacts with Neuropilin-21,2.GIPC1 expression is upregulated in breast, ovarian and pancreas cancers2.

Alternative names: GIPC1, PDZ domain-containing protein GIPC1, GIPC, GAIP C-terminus-interacting protein, RGS-GAIP-interacting protein, Synectin, NIP, TIP-2

ID gène: 10755

NCBI Accession: NM_005716

UniProt: O14908

Pathways: Dicarboxylic Acid Transport