KCNIP2 anticorps (Cytosolic, N-Term)

N° du produit ABIN7043296

Cet anticorps Lapin Polyclonal détecte spécifiquement KCNIP2 dans WB, IHC et IF. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour KCNIP2 anticorps (Cytosolic, N-Term) (ABIN7043296)

Antigène: KCNIP2 (Kv Channel Interacting Protein 2 (KCNIP2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNIP2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-KCNIP2 anticorps

Épitope: AA 2-15, Cytosolic, N-Term

Fonction: A Rabbit Polyclonal Antibody to KChIP2 Subunit

Réactivité croisée: Humain, Souris, Rat

Homologie: Mouse - identical Rat - 13,14 amino acid residues identical

Attributs du produit: Anti-KChIP2 Antibody (ABIN7043296, ABIN7045040 and ABIN7045041) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize KChIP2 from rat, mouse, and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)RGQGRKESLSDSRD, corresponding to amino acid residues 2-15 of human KChIP2

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:400

IP: The optimal concentration should be determined by the user

Commentaires:

Cited Application: IP|ICC

Negative Control: (ABIN7235841)

Blocking Peptide: (ABIN7235841)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur KCNIP2

Antigène: KCNIP2 (Kv Channel Interacting Protein 2 (KCNIP2))

Autre désignation: KCNIP2

Sujet:

Synonyms: KCNIP2, KV channel-interacting protein 2, A-type potassium channel modulatory protein 2, Cardiac voltage-gated potassium channel modulatory subunit

Description: KChIPs belong to the family of small cytosolic calcium-binding proteins and consist of four different KChIP isoforms ranging between 216 and 270 amino acids. They all have a reasonably conserved core region of 185 amino acids and a heterogeneous N-terminal. KChIPs have calcium-binding EF hands which appear to be important for modulation of KV channels but not for CaV channels1.The cardiac KChIP2 gene generates three protein isoforms of 220, 252, and 270 amino acids via alternative splicing of exons 2 and 3. It is well established that KChIP2 functionally increases peak KV4 current, slows channel inactivation and accelerates recovery from inactivation. Furthermore, KChIP2 has been reported to increase ICa,L and suggested to decrease KV1.5 cell surface expression and facilitate INa2 .All four KChIP mRNAs are found in the brain, however only KChIP2 is expressed in the heart3. KChIP2 is expressed heterogeneously across the canine and human left and right ventricular free wall with higher concentrations in epicardium compared to endocardium4.Mice deficient for KChIP2 exhibit normal cardiac structure and function but display a prolonged elevation in the ST segment on the electrocardiogram. The KChIP2-/- mice are highly susceptible to the induction of cardiac arrhythmias5.

ID gène: 30819

NCBI Accession: NM_014591

UniProt: Q9NS61