LRRTM1 anticorps (Extracellular)

N° du produit ABIN7043302

Cet anticorps Lapin Polyclonal détecte spécifiquement LRRTM1 dans WB, IHC et IF. Il présente une réactivité envers Souris.

Aperçu rapide pour LRRTM1 anticorps (Extracellular) (ABIN7043302)

Antigène: LRRTM1 (Leucine Rich Repeat Transmembrane Neuronal 1 (LRRTM1))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LRRTM1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-LRRTM1 anticorps

Épitope: AA 334-346, Extracellular

Fonction: A Rabbit Polyclonal Antibody to LRRTM1

Specificité: Extracellular, N-terminus

Réactivité croisée: Souris, Rat

Homologie: rat - 12,Mouse,13 amino acid residues identical, human - 11

Attributs du produit: Anti-LRRTM1 (extracellular) Antibody (ABIN7043302, ABIN7044730 and ABIN7044731) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It recognizes an extracellular epitope and can potentially detect the protein in living cells. It has been designed to recognize LRRTM1 from human, rat, and mouse samples.

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)GRYDANLQ(S)ASPE, corresponding to amino acid residues 334-346 of mouse LRRTM1

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200

Application Dilutions Western blot wb: 1:400

Commentaires:

Negative Control: (ABIN7235868)

Blocking Peptide: (ABIN7235868)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur LRRTM1

Antigène: LRRTM1 (Leucine Rich Repeat Transmembrane Neuronal 1 (LRRTM1))

Autre désignation: LRRTM1

Sujet: Leucine-rich repeat transmembrane neuronal protein 1,Leucine rich repeat transmembrane neuronal 1 (LRRTM1) is a synaptogenic, cell adhesion protein that contributes to the regulation of synapse density and synaptic transmission. The LRRTM family in mammals includes four postsynaptic proteins, which have been shown to interact with presynaptic neurexins and heparan sulphate proteoglycan glypican on the presynaptic side1. In human and mouse genomes, LRRTM1 is encoded by a single exon and is predominantly expressed in the nervous system. LRRTM1 is a single-membrane-spanning transmembrane protein and its structure contains ten N-terminal LRR repeats, a single pass transmembrane domain, and a cytoplasmic C-terminal tail comprising a PDZ-binding motif1.Mutations in human genes encoding the LRRTM proteins are implicated in cognitive disorders. In particular, LRRTM1 is associated to human handedness and schizophrenia1,2. Studies on Lrrtm1 knockout mice shows deficits in behavioral responses to stressful situations and novel objects, spatial memory and social discrimination deficits3. LRRTM1 mutant mice display impairment in visual behaviors, suggesting a functional role of LRRTM1 in retinothalamic convergence in vision4.

Alternative names: LRRTM1, Leucine-rich repeat transmembrane neuronal protein 1

ID gène: 74342

NCBI Accession: NM_178839

UniProt: Q8K377

Pathways: Synaptic Membrane