OPRK1 anticorps (Extracellular)

N° du produit ABIN7043402

L’anticorps Lapin Polyclonal anti-OPRK1 a été validé pour WB, IHC, FACS et LCI. Il convient pour détecter OPRK1 dans des échantillons de Rat.

Aperçu rapide pour OPRK1 anticorps (Extracellular) (ABIN7043402)

Antigène: OPRK1 (Opioid Receptor, kappa 1 (OPRK1))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OPRK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Détail du produit anti-OPRK1 anticorps

Épitope: AA 39-55, Extracellular

Fonction: A Rabbit Polyclonal Antibody to ?-Opioid Receptor (OPRK1)

Specificité: Extracellular, N-terminus

Réactivité croisée: Souris, Rat

Homologie: human - 15,17 amino acid residues identical,Mouse -16

Attributs du produit: Anti-κ-Opioid Receptor (OPRK1) (extracellular) Antibody is directed against an epitope of the rat κ-opioid receptor. Anti-κ-Opioid Receptor (OPRK1) (extracellular) Antibody (ABIN7043402, ABIN7044889 and ABIN7044890) can be used in western blot analysis. The antibody recognizes an extracellular epitope and thus is ideal for detecting the receptor in living cells. The antibody was designed to recognize κ-opioid receptor from mouse, rat and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)NGSVGSEDQQLEPAHIS, corresponding to amino acid residues 39-55 of rat kappa-Opioid receptor

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300

Application Dilutions Western blot wb: 1:200

Commentaires:

Cited Application: IHC

Negative Control: (ABIN7236171)

Blocking Peptide: (ABIN7236171)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur OPRK1

Antigène: OPRK1 (Opioid Receptor, kappa 1 (OPRK1))

Autre désignation: OPRK1

Sujet: Kappa-type opioid receptor, KOR-1, Opiate receptor kappa 1,Endogenous opiates such as endorphins, endomorphins, and enkephalins, as well as opiate drugs (including morphine) exert their effects by binding to opioid receptors. Three "classic" types of opioid receptors have been identified: mu (μ)-opioid (MOP) receptor, delta (δ)-opioid (DOP) receptor, and kappa (κ)-opioid (KOP) receptor1. Recently, the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor was also described. Despite its significant sequence homology, its pharmacological profile differs greatly from those of the classic μ, δ, and κ receptors2.The opioid receptors belong to the G protein-coupled receptor (GPCR) superfamily whose members share a common structure of seven putative transmembrane domains, an extracellular amino terminus, a cytoplasmic carboxyl terminus, and a third intracellular loop important for binding G proteins1.All three classic opioid receptors mediate opioid-induced analgesia. Supraspinal analgesia is mainly mediated by the μ-opioid receptor, whereas μ-, δ-, and κ-receptors participate in the control of pain at the spinal level3. The opioid receptors also mediate the mood-altering properties of opioids4.κ-Opioid Receptor is activated by the endogenous peptide dynorphin. Malfunction of their signaling may be involved in epilepsy, addiction, depression, schizophrenia, and chronic pain5.κ-Opioid Receptor is localized to a number of regions in the brain, as well as the spinal cord, the enteric nervous system and the digestive system5.

Alternative names: Kappa-Opioid Receptor (OPRK1), Kappa-type opioid receptor, KOR-1, Opiate receptor kappa 1

ID gène: 29335

NCBI Accession: NM_000912

UniProt: P34975