PTH1R anticorps (1st Extracellular Loop)

N° du produit ABIN7043429

L’anticorps anti-PTH1R Polyclonal Lapin est utilisé pour la détection de PTH1R dans des échantillons de Rat. Il a été validé pour WB, IHC, IF, IC et LCI.

Aperçu rapide pour PTH1R anticorps (1st Extracellular Loop) (ABIN7043429)

Antigène: PTH1R (Parathyroid Hormone 1 Receptor (PTH1R))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTH1R est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC), Live Cell Imaging (LCI)

Détail du produit anti-PTH1R anticorps

Épitope: 1st Extracellular Loop, AA 241-255

Fonction: A Rabbit Polyclonal Antibody to Parathyroid Hormone 1 Receptor

Réactivité croisée: Humain, Souris, Rat

Homologie: Mouse - identical, human - 14,15 amino acid residues identical

Attributs du produit: Anti-PTH1R (extracellular) Antibody (ABIN7043429, ABIN7045112 and ABIN7045113) is a highly specific antibody directed against an epitope of the rat Parathyroid hormone 1 receptor. The antibody can be used in western blot, immunohistochemistry, and live cell imaging applications. It has been designed to recognize PTH1R from human, mouse, and rat samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)DAVLYSGFTLDEAER, corresponding to amino acid residues 241-255 of rat PTH1R

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:50

IHC: 1:60

IP: The optimal concentration should be determined by the user

Commentaires:

Cited Application: IFC

Negative Control: (ABIN7236233)

Blocking Peptide: (ABIN7236233)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur PTH1R

Antigène: PTH1R (Parathyroid Hormone 1 Receptor (PTH1R))

Autre désignation: PTH1R

Sujet:

Synonyms: Parathyroid hormone 1 receptor, PTH/PTHrP type I receptor, PTH1 receptor, PTHR, PTHR1

Description: The parathyroid hormone receptor type 1 (PTHR1) is bound and activated by two peptide hormones: the parathyroid hormone (PTH) secreted by the parathyroid gland and by parathyroid hormone related peptide (PTHrP) which is produced locally in many tissues. Although these two peptides bind the same receptor, they exert different actions. PTH regulates the concentrations of Ca2+, phosphate ions and vitamin D in the blood, stimulates bone formation/resorption and is distributed to the kidneys where it regulates Ca2+ and phosphate transport, and is also detected in the liver1-3. PTHrP, on the other hand, plays a critical role early in development of bone, heart, mammary glands and other tissues, and is detected in the circulation only during lactation and secreted by some tumors1,2,4,5. PTHR1 is obviously localized to all areas and tissues where PTH and PTHrP are known to exert their effects (i.e. bone, kidney, blood, heart, etc.).PTHR1 belongs to the superfamily of G-protein coupled receptors. Like all members, PTHR1 has seven transmembrane spanning domains, an extracellular N-terminus and an intracellular C-terminal tail. Upon activation, the receptor couples to either Gs and Gq thereby activating adenylate cyclase and phospholipase C (PLC) respectively. In osteosarcoma cells, PTHR1 can also couple Gα2,6,7.PTH is being used today to treat osteoporosis, as a factor promoting bone formation. Mutations in PTHR1 are associated with Jansen's disease (hypercalcemia and dwarfism) and Eiken syndrome (cartilage tumors of bone)2,8-10.

ID gène: 56813

NCBI Accession: NM_000316

UniProt: P25961

Pathways: Regulation of Carbohydrate Metabolic Process