Plexin C1 anticorps (Extracellular)

N° du produit ABIN7043439

Cet anticorps anti-Plexin C1 est un anticorps Lapin Polyclonal détectant Plexin C1 dans WB, IHC, FACS et LCI. Adapté pour Humain.

Aperçu rapide pour Plexin C1 anticorps (Extracellular) (ABIN7043439)

Antigène: Plexin C1 (PLXNC1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Plexin C1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Détail du produit anti-Plexin C1 anticorps

Épitope: AA 860-874, Extracellular

Fonction: A Rabbit Polyclonal antibody to Plexin-C1 (extracellular)

Specificité: Extracellular, N-terminus.

Réactivité croisée: Humain, Souris, Rat

Homologie: Mouse - identical Rat - 14 out of 15 amino acid residues identical

Attributs du produit: A rabbit polyclonal antibody to Plexin-C1 (extracellular)

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: Peptide (C)EVKIQKENDNFNISK, corresponding to amino acid residues 860 - 874 of human Plexin-C1

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200

Application Dilutions Western blot wb: 1:200

Commentaires:

Negative Control: (ABIN7236272)

Blocking Peptide: (ABIN7236272)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur Plexin C1

Antigène: Plexin C1 (PLXNC1)

Autre désignation: PLXNC1

Sujet: Virus-Encoded Semaphorin Protein Receptor, VESPR, CD232, PLXNC1,Plexin-C1 also known as Virus-encoded semaphorin protein receptor, is a ~210 kDa type I transmembrane receptor that regulates cytoskeletal remodeling and adhesion in human melanocytes.It belongs to the family of Plexin receptors, these are type I transmembrane proteins (A-D) that share a highly conserved cytoplasmic domain and an intracellular region containing an intrinsic Ras-GTPase activating (GAP) domain. Plexin receptors bind semaphorins: a class of secreted and membrane proteins 1. The natural ligand of Plexin C1 is Semaphorin -7A (#ASR-077).Plexin-C1 is highly expressed in melanocytes, neurons, neutrophils, dendritic cells and pre-osteoblasts and it has a complex effect on migration of melanocytes and melanoma, that depends on the phase of progression of this type of cancer 2,3. It also has additional roles in the partitioning of paraventricular and supraoptic neurons in the hypothalamus, in the development of inflamation and in inhibition of neutrophils phagocytosis 3,4.

Alternative names: Virus-Encoded Semaphorin Protein Receptor, VESPR, CD232, PLXNC1

ID gène: 10154

NCBI Accession: NM_005761

UniProt: O60486