RTN4R anticorps (Extracellular)

N° du produit ABIN7043601

Cet anticorps anti-RTN4R Polyclonal Lapin (ABIN7043601) détecte spécifiquement RTN4R dans WB, IHC, FACS, IF, IC et LCI. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour RTN4R anticorps (Extracellular) (ABIN7043601)

Antigène: RTN4R (Reticulon 4 Receptor (RTN4R))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RTN4R est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Immunochromatography (IC), Live Cell Imaging (LCI)

Détail du produit anti-RTN4R anticorps

Épitope: AA 366-381, Extracellular

Fonction: A Rabbit Polyclonal Antibody to Nogo Receptor

Réactivité croisée: Humain, Souris, Rat

Homologie: Mouse,rat - 15,16 amino acid residues identical

Attributs du produit: Anti-Nogo Receptor (extracellular) Antibody is directed against an extracellular epitope of the human Nogo receptor. Anti-Nogo Receptor (extracellular) Antibody (ABIN7043601, ABIN7044757 and ABIN7044758) can be used in western blot, immunohistochemistry and live cell imaging applications. It has been designed to recognize NgR from human, mouse and rat samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)GDSPPGNGSGPRHIND corresponding to amino acid residues 366-381 of the human Nogo receptor

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Cited Application: IHC

Negative Control: (ABIN7236730)

Blocking Peptide: (ABIN7236730)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur RTN4R

Antigène: RTN4R (Reticulon 4 Receptor (RTN4R))

Autre désignation: RTN4R

Sujet:

Synonyms: NogoR, Nogo-R, NgR, NgR1, Nogo-66 receptor, Reticulon 4 receptor, RTN4R

Description: The Nogo receptor is a leucine-rich repeat (LRR) containing protein with a glycosylphosphatidylinositol (GPI) anchored C-terminus. The receptor was identified on the basis of its ability to bind with high affinity to Nogo-A a member of the reticulon family expressed in the cell membrane of oligodendrocytes.1Nogo-A attracted attention when it was demonstrated that it is a myelin protein capable of inhibiting axonal growth following nerve injury.2,3 Other myelin proteins also identified as axonal growth inhibitors are the myelin-associated glycoprotein (MAG) a sialic-dependent immunoglobulin-like family member lectin (SIGLEC) and the oligodendrocyte myelin glycoprotein (OmgP) which is a GPI-anchored membrane protein. Remarkably, despite their structural diversity, all three axonal growth inhibitors bind to the Nogo receptor with high affinity.4,5Since the Nogo receptor is a GPI-anchored protein it was expected that it would require another protein component to transduce the Nogo-A binding information into the responding neurons interior. Indeed, it was shown that the neurotrophin receptor p75 (p75NTR) interacts with Nogo receptor and a third protein termed LINGO-1 to mediate axonal growth inhibition signaling.6,7

ID gène: 65078

NCBI Accession: NM_023004

UniProt: Q9BZR6

Pathways: Neurotrophin Signaling Pathway