SIGMAR1 anticorps (C-Term, Intracellular)

N° du produit ABIN7043628

Cet anticorps anti-SIGMAR1 Polyclonal Lapin (ABIN7043628) détecte spécifiquement SIGMAR1 dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour SIGMAR1 anticorps (C-Term, Intracellular) (ABIN7043628)

Antigène: SIGMAR1 (sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIGMAR1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Classe de qualité: KO Validated

Détail du produit anti-SIGMAR1 anticorps

Épitope: AA 113-126, C-Term, Intracellular

Fonction: A Rabbit Polyclonal Antibody to Sigma-1 Receptor

Réactivité croisée: Humain, Souris, Rat

Homologie: Rat,mouse - identical

Attributs du produit: Anti-Sigma-1 Receptor Antibody (ABIN7043628, ABIN7044522 and ABIN7044523) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot analysis. It has been designed to recognize SIGMAR1 from human, rat, and mouse samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)SRGHSGRYWAEISD, corresponding to amino acid residues 113-126 of human SIGMAR1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236803)

Blocking Peptide: (ABIN7236803)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur SIGMAR1

Antigène: SIGMAR1 (sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1))

Autre désignation: SIGMAR1

Sujet:

Synonyms: SIGMAR1, OPRS1, Sigma non-opioid intracellular receptor 1, SIG-1R, Aging-associated gene 8 protein, SR31747-binding protein, SRBP

Description: Sigma receptors were first identified as a subtype of opioid receptors. The different members of the family are differentially distributed in various parts of the CNS and are responsible for a vast range of functions and behaviors1. Today, sigma receptors are mostly considered to be a separate receptor family with two main subtypes characterized.The sigma-1 receptor is encoded by a gene baring the same name and is a protein of 223 amino acids with two transmembrane domains and a typical endoplasmic reticulum localized signal near its short N terminus. Sigma receptors are mostly detected in the central nervous system with a high density in the spinal cord, pons, medulla oblongata, red nucleus, cerebellum and hippocampus.Sigma-1 is mainly localized on the mitochondrial associated endoplasmic reticulum membrane (MAM), forming a BiP chaperone structure with high sensitivity to the calcium ion. When activated by agonists such as cocaine or analgesics, sigma-1 receptors separate from BiP and translocate from MAM to other parts of the cell. Through regulation of inositol triphosphate (IP3) receptors, NMDA receptors, dopamine receptors and voltage-gated Ca2+ channels, sigma-1 receptors can influence TCA cycle, oxidative stress, mitochondrial function, neuron plasticity and the release of various neurotransmitters.The exact etiology and pathophysiology of Alzheimer's disease is not fully understood. A few hypotheses suggest the involvement of Sigma-1 in the progression of Alzheimer's disease. The suggested mechanisms include protection from Aβ toxicity, prevention of Tau protein hyperphosphorylation and the upregulation of acetylcholine release2.

ID gène: 10280

NCBI Accession: NM_005866

UniProt: Q99720

Pathways: SARS-CoV-2 Protein Interactome