SLC2A3 anticorps (Extracellular)

N° du produit ABIN7043696

L’anticorps anti-SLC2A3 Polyclonal Lapin est utilisé pour la détection de SLC2A3 dans des échantillons de Rat. Il a été validé pour WB, IHC, FACS et IF.

Aperçu rapide pour SLC2A3 anticorps (Extracellular) (ABIN7043696)

Antigène: SLC2A3 (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 3 (SLC2A3))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC2A3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Détail du produit anti-SLC2A3 anticorps

Épitope: AA 39-52, Extracellular

Fonction: A Rabbit Polyclonal Antibody to Glucose Transporter 3

Specificité: 1st extracellular loop

Réactivité croisée: Souris, Rat

Réactivité croisée (Details): Will not recognize human GLUT3.

Homologie: Mouse - identical

Attributs du produit: Anti-GLUT3 (extracellular) Antibody (ABIN7043696, ABIN7044485 and ABIN7044486) is a highly specific antibody directed against an epitope of the rat Glucose Transporter 3 protein. The antibody can be used in western blot, immunohistochemistry, and live cell flow cytometry applications. The antibody has been designed to recognize GLUT3 from rat and mouse samples. It will not recognize GLUT3 from human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)KDFLNYTLEERLED, corresponding to amino acid residues 39-52 of rat Glucose Transporter 3

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200

Application Dilutions Western blot wb: 1:400

Commentaires:

Negative Control: (ABIN7237002)

Blocking Peptide: (ABIN7237002)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur SLC2A3

Antigène: SLC2A3 (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 3 (SLC2A3))

Autre désignation: SLC2A3

Sujet: Glucose transporter 3, Facilitated glucose transporter member 3, SLC2A3,The GLUT protein family is encoded by the SLC2 genes and are a member of the major facilitator superfamily of membrane transporters. GLUTs are recognized as key regulators of whole-body glucose homeostasis, and are responsible for the uptake of carbohydrate-derived glucose by cells. There are 14 GLUT isoforms divided into 3 different group classes based on sequence similarity and structural and functional characteristics1,2.GLUT3 is a low-Km protein responsible for glucose uptake into neurons. It is predominantly expressed in neurons and is commonly called "neuronal glucose transporter". The protein contains 12 membrane-spanning domains, an N-linked glycosylation site in loop 1 responsible for high-affinity transport of glucose, and intracellular NH2- and COOH- termini. In addition, there are several conserved residues and motifs designated "sugar transporter signatures"1,2.GLUT3 levels are high in some malignant glioma cells compared to normal glial cells and therefore may be used as a therapeutic target in some cancer treatment3.

Alternative names: GLUT3, Glucose transporter 3, Facilitated glucose transporter member 3, SLC2A3

ID gène: 100909595

NCBI Accession: NM_006931

UniProt: Q07647

Pathways: L'effet Warburg