Stim2 anticorps (Intracellular)

N° du produit ABIN7043782

Cet anticorps Lapin Polyclonal détecte spécifiquement Stim2 dans WB, IHC, IF et IC. Il présente une réactivité envers Humain.

Aperçu rapide pour Stim2 anticorps (Intracellular) (ABIN7043782)

Antigène: Stim2 (Stromal Interaction Molecule 2 (Stim2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Stim2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)

Classe de qualité: KO Validated

Détail du produit anti-Stim2 anticorps

Épitope: AA 583-597, Intracellular

Fonction: A Rabbit Polyclonal Antibody to STIM2

Specificité: Intracellular, C-terminus

Réactivité croisée: Humain, Souris, Rat

Homologie: Rat,mouse,bovine - identical

Attributs du produit: Anti-STIM2 Antibody (ABIN7043782, ABIN7044028 and ABIN7044029) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot, immunocytochemistry, and immunohistochemistry applications. It has been designed to recognize STIM2 from human, rat, and mouse samples.

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: SAEKQWEVPDTASEC, corresponding to amino acid residues 583-597 of human STIM2

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100

Application Dilutions Western blot wb: 1:200

Commentaires:

Cited Application: IP|ICC

Negative Control: (ABIN7237296)

Blocking Peptide: (ABIN7237296)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur Stim2

Antigène: Stim2 (Stromal Interaction Molecule 2 (Stim2))

Autre désignation: STIM2

Sujet: Stromal interaction molecule 2,Cytosolic Ca2+ has long been known to act as a key second messenger in many intracellular pathways including synaptic transmission, muscle contraction, hormonal secretion, cell growth and proliferation.1,2 The mechanism controlling the influx of intracellular Ca2+ either by calcium-release-activated Ca2+ channels (CRAC) or from intracellular stores has lately become the focus of intense research.Recently, several key players of the store-operated complex have been identified: the Orai family consists of three members: Orai1-3, and the STIM family, which consists of two members, STIM1 and STIM2.3 Orai1 (also known as CRACM1) acts as the store-operated calcium channel (SOC) and STIM1 as the endoplasmic reticulum (ER) Ca2+ sensor.3,4While STIM1 appears to be localized intracellularly at the ER membrane and at a much lower extent on the cell surface of several cell types, STIM2 appears to be localized solely at the ER membrane.5 The function of STIM2 still remains elusive and several models have been suggested.6-8

Alternative names: STIM2, Stromal interaction molecule 2

ID gène: 57620

NCBI Accession: NM_020860

UniProt: Q9P246

Pathways: TCR Signaling, BCR Signaling