SYN2 anticorps (Domain G, Intracellular)

N° du produit ABIN7043787

Cet anticorps anti-SYN2 Polyclonal Lapin (ABIN7043787) détecte spécifiquement SYN2 dans WB, IHC et IF. L’anticorps est réactif avec des échantillons de Rat.

Aperçu rapide pour SYN2 anticorps (Domain G, Intracellular) (ABIN7043787)

Antigène: SYN2 (Synapsin II (SYN2))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SYN2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-SYN2 anticorps

Épitope: AA 438-450, Domain G, Intracellular

Fonction: A Rabbit Polyclonal Antibody to Synapsin II

Réactivité croisée: Souris, Rat

Réactivité croisée (Details): This antibody will recognize both canonical isoforms (also known as Synapsin IIa) and the shorter isoform (Synapsin-IIb).

Homologie: Mouse - identical, human- 12,13 amino acid residues identical

Attributs du produit: Anti-Synapsin II (SYN2) Antibody (ABIN7043787, ABIN7044660 and ABIN7044661) is a highly selective antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize Synapsin II from mouse, human, and rat samples. This antibody will recognize both canonical isoforms (also known as Synapsin IIa) and the shorter isoform (Synapsin IIb).

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)SGTLKEPDSSKTP, corresponding to amino acid residues 438-450 of rat Synapsin-2

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7237311)

Blocking Peptide: (ABIN7237311)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur SYN2

Antigène: SYN2 (Synapsin II (SYN2))

Autre désignation: SYN2

Sujet:

Synonyms: Synapsin-2

Description: Synapsins are a family of ten homologous neuronal phosphoproteins evolutionarily conserved in invertebrate and vertebrate organisms. Synapsins appear to be crucial determinants for the fine-tuning of synaptic transmission and for synaptic remodeling. This is particularly evident in several paradigms of short-term plasticity (STP), which are specifically affected by mutations or malfunctioning of synapsin proteins. Notably, knockout of synapsin-2 in mice causes fully generalized forebrain seizures from the age of 2 months1.All synapsins, including synapsin-2, are composed of a highly homologous N-terminal region, and a more variable C-terminus. The N-terminal homologous region can be divided in three domains, namely domain A, B and C, which, except for domain B, are highly conserved across isoforms and species. Domain A is contains the phosphorylation site for PKA and CaMKI. Domain B, rich in small amino acids, is considered as a linker region connecting domain A to domain C. Domain C is a large region of about 300 amino acids, containing both hydrophobic and highly charged sequences with the potential to assume α-helix and β-sheet conformations. It shows extensive homology amongst the various members of the family, and mediates the core functions of synapsins1.

ID gène: 29179

NCBI Accession: NM_133625

UniProt: Q63537