beta Synuclein anticorps (Intracellular)

N° du produit ABIN7043801

L’anticorps Lapin Polyclonal anti-beta Synuclein a été validé pour WB. Il convient pour détecter beta Synuclein dans des échantillons de Rat.

Aperçu rapide pour beta Synuclein anticorps (Intracellular) (ABIN7043801)

Antigène: beta Synuclein (SNCB) (Synuclein, beta (SNCB))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp beta Synuclein est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-beta Synuclein anticorps

Épitope: AA 86-99, Intracellular

Fonction: A Rabbit Polyclonal Antibody to β-Synuclein

Specificité: Intracellular, C-terminus

Réactivité croisée: Humain, Souris, Rat

Réactivité croisée (Details): Specific for β-synuclein. No cross-reactivity with α-synuclein.

Homologie: Mouse,human - identical

Attributs du produit: Anti-Beta-Synuclein Antibody (ABIN7043801, ABIN7045182 and ABIN7045183) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot analysis. It has been designed to recognize β-synuclein from human, mouse, and rat samples. The antibody is specific for β-synuclein. It will not cross-react with α-synuclein.

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)KEEFPTDLKPEEVA, corresponding to amino acid residues 86-99 of rat beta-synuclein

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: 1:200

Commentaires:

Negative Control: (ABIN7237362)

Blocking Peptide: (ABIN7237362)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur beta Synuclein

Antigène: beta Synuclein (SNCB) (Synuclein, beta (SNCB))

Autre désignation: SNCB

Sujet: β-Synuclein, Synuclein beta, PNP 14, SNCB,β-Synuclein is a presynaptic protein that plays an important role in neuronal plasticity and synaptic vesicle regulation. The synuclein family includes three members: α, β and γ isoforms. The presynaptic proteins are detected in the neocortex, hippocampus, striatum, thalamus, and cerebellum regions1,2. β-Synuclein has been shown to act as a negative regulator of α-synuclein aggregation both in vivo and in vitro1,2. Structure wise, the protein contains a highly conserved N-terminal domain which includes a repetitive amino acid motif, and a more divergent and highly acidic stretch at the C-terminal domain2,3.Studies have shown overexpressed mRNA levels of β-synuclein in Parkinson's disease suggesting that the protein has a valuable role in maintaining homeostasis in the disease pathology. In addition, studies have shown the action of β-synuclein as a neurodegeneration-inducing factor that can cause cell loss when expressed in rat brains1,2.β-Synuclein is also implicated with dementia involving Lewy bodies. To date, two mutations in the protein, V70M and P123H, have been identified in the sporadic and familial disease3.

Alternative names: Beta-Synuclein, beta-Synuclein, Synuclein beta, PNP 14, SNCB

ID gène: 113893

NCBI Accession: NM_001001502

UniProt: Q63754