TAAR1 anticorps (C-Term, Intracellular)

N° du produit ABIN7043812

Cet anticorps Lapin Polyclonal détecte spécifiquement TAAR1 dans WB. Il présente une réactivité avec des échantillons de Rat.

Aperçu rapide pour TAAR1 anticorps (C-Term, Intracellular) (ABIN7043812)

Antigène: TAAR1 (Trace Amine Associated Receptor 1 (TAAR1))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TAAR1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-TAAR1 anticorps

Épitope: AA 313-325, C-Term, Intracellular

Fonction: A Rabbit Polyclonal Antibody to Trace Amine Receptor 1

Réactivité croisée: Humain, Souris, Rat

Homologie: Mouse,human - 12,13 amino acid residues identical

Attributs du produit: Anti-Trace Amine Receptor 1 (TAAR1) Antibody is directed against an epitope of the rat Trace amine-associated receptor 1. Anti-Trace Amine Receptor 1 (TAAR1) Antibody (ABIN7043812, ABIN7045324 and ABIN7045325) can be used in western blot analysis. It has been designed to recognize TAAR1 from rat, mouse and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)KMVLFGKIFQKDS, corresponding to amino acid residues 313-325 of rat TAAR1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7237397)

Blocking Peptide: (ABIN7237397)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur TAAR1

Antigène: TAAR1 (Trace Amine Associated Receptor 1 (TAAR1))

Autre désignation: TAAR1

Sujet:

Synonyms: Trace amine-associated receptor 1, TaR-1, TA1, TRAR1

Description: Trace amines are compounds, such as p-tyramine and tryptamine, found in the body in trace amounts. These substances were believed to mainly modulate aminergic pathways. However, they were found to activate Trace amino associated receptors (TAARs), members of the G-protein coupled receptor (GPCRs) superfamily1.Trace amine receptor 1 (TAAR-1) is part of the Rhodopsin family of GPCRs. Five other putative genes are thought to encode TAAR receptors. This receptor has a seven transmembrane domain with short extracellular N- and intracellular C- terminal domains.TAAR-1 couples Gs, thus leading to an increase in intracellular cAMP levels. Its signaling might be enhanced by monoamine transporters, and activation of TAAR-1 may also affect monoamine transport function. The receptor also inhibits PKA and PKC mediated dopamine uptake and PKC mediated dopamine efflux2. It is also possible that it forms heterodimers with dopamine receptors, thus influencing dopamine transmission3.In humans, this receptor is mainly expressed in the stomach but is also detected in the lungs, small intestine and many cerebral and cerebellar tissues including the amygdala, hypothalamus and others4.In experiments conducted in mice it was shown that TAAR-1 knockout mice display increased stimulation effects of d-amphetamine, greater levels of extracellular monoamine and hyperactivity. These effects are related to clinical conditions such as ADHD, psychosis and other psychiatric problems5. Additional studies on TAAR family receptors may be helpful in finding cutting edge treatment.

ID gène: 113914

NCBI Accession: NM_138327

UniProt: Q923Y9