Recombinant IL-2 anticorps

N° du produit ABIN7072227

Cet anticorps anti-IL-2 est un anticorps Lapin Chimeric détectant IL-2 dans WB, ELISA, FACS, IF, Crys et LA. Adapté pour Humain.

Aperçu rapide pour Recombinant IL-2 anticorps (ABIN7072227)

Antigène: IL-2 (IL2) (Interleukin 2 (IL2))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Cet anticorp IL-2 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Crystallization (Crys), Latex Agglutination (LA)

Clone: LNKB-2

Détail du produit anti-IL-2 anticorps

Fonction: Anti-IL-2 [LNKB-2], Rabbit IgG, kappa

Specificité: This antibody binds human IL-2 at the 59-72 site of the IL-2 sequence.

Attributs du produit:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Isotype: IgG kappa

Information d'application

Indications d'application: This antibody was quantified by ELISA and used for latex-agglutination analysis of human IL-2. It was measured to bind human IL-2 with high affinity (Ka ~ 3 x 10⁸ M^-1) (Lunev et al., 1990, PMID: 1718463). This antibody has been used successfully for WB and FACS (Stratieva-Taneeva et al., 1993, PMID: 8359822). The crystal structure characterization of the Fab version of this antibody was performed (Fokin et al., 2000, PMID: 11040993). Further crystallization of the Fab version of this antibody with an antigenic peptide revealed that the antibody-antigen complexation involves a significant rearrangement of the epitope-containing region of the IL-2 with retention of the α-helical character of the epitope fragment (Afonin et al., 2001, PMID: 11468348).

Commentaires:

This chimeric rabbit antibody was made using the variable domain sequences of the original murine IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur IL-2

Antigène: IL-2 (IL2) (Interleukin 2 (IL2))

Autre désignation: IL-2

Sujet: Interleukin 2, LNKB2

UniProt: P60568

Pathways: Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation