Recombinant CD70 anticorps

N° du produit ABIN7072496

L’anticorps Rat Monoclonal anti-CD70 a été validé pour WB, FACS, IF et BP. Il convient pour détecter CD70 dans des échantillons de Souris.

Aperçu rapide pour Recombinant CD70 anticorps (ABIN7072496)

Antigène: CD70 (CD70 Molecule (CD70))

Type d'anticorp: Recombinant Antibody

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp CD70 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Blocking Peptide (BP)

Clone: TAN1-6

Détail du produit anti-CD70 anticorps

Fonction: Anti-CD70 [TAN1-6], Rat IgG2a, kappa

Specificité: This antibody is specific for murine CD70, a 30-33 kDa type II transmembrane glycoprotein. CD70 is a member of the TNF family and is expressed by activated mouse T and B lymphocytes. Interaction of CD70 with CD27, its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation.

Attributs du produit:

Original Species of Ab: Rat

Original Format of Ab: IgG2a

Purification: Protein A affinity purified

Immunogène: This antibody was raised by immunising LOU rats with soluble recombinant CD70:Fc fusion protein

Isotype: IgG2a kappa

Information d'application

Indications d'application: This antibody has been used in various FACS analyses to reveal a critical role for CD70 in CD8 T cell priming by CD40-licensed antigen-presenting cells (Taraban et al, 2004), to demonstrate the differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells (Bak et al, 2012), to examine how temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8(+) T cell responses to influenza (Ballesteros-Tato et al, 2010), and to show that CD70 is downregulated by interaction with CD27 (Kuka et al, 2013). In addition, this antibody has been used in vivo to block the CD70-CD27 interaction as part of the two studies examining how CD70 is critically required for the priming of CD8+ T cells (Taraban et al, 2004, Taraban et al, 2006).

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur CD70

Antigène: CD70 (CD70 Molecule (CD70))

Autre désignation: CD70

Sujet: TNFSF7, CD27 ligand, CD27-L, Cd27l, CD27LG, CD70 antigen, Ki-24 antigen, Tnfsf7, tumor necrosis factor (ligand) superfamily, member 7, Tumor necrosis factor ligand superfamily member 7

UniProt: O55237

Pathways: Cancer Immune Checkpoints