Recombinant CCR7 anticorps

N° du produit ABIN7072672

Cet anticorps Lapin Chimeric détecte spécifiquement CCR7 dans FACS, IP et Func. Il présente une réactivité envers Souris.

Aperçu rapide pour Recombinant CCR7 anticorps (ABIN7072672)

Antigène: CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))

Type d'anticorp: Recombinant Antibody

Reactivité: Souris

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Cet anticorp CCR7 est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)

Clone: 4B12

Détail du produit anti-CCR7 anticorps

Fonction: Anti-CCR7 [4B12], Rabbit IgG, kappa

Specificité: This antibody is specific to the mouse CCR7 protein, which was confirmed by immunoprecipitation (Ritter et al, 2004).

Attributs du produit:

Original Species of Ab: Rat

Original Format of Ab: IgG2a

Purification: Protein A affinity purified

Immunogène: This antibody was raised by immunizing rats with mouse CCR7 antigen.

Isotype: IgG kappa

Information d'application

Indications d'application: This antibody was used for flow cytometry and the staining quality can be improved by incubation at 37 °C (Britschgi et al, 2008). This antibody is widely used to monitor the activation of dendritic cells in mice (Ohl et al, 2004, Ritter et al, 2004, Zhao et al, 2019). It was also utilized in immunoprecipitation of the CCR7 receptor protein (Ritter et al, 2004). The antibody does not interfere with ligands binding to the CCR7 receptor, which was confirmed by a transmigration assay (Ritter et al, 2004). It does not interfere with T-cell migration (Ritter et al, 2004). The antibody also is not agonistic as it does not activate the receptor (Ritter et al, 2004).

Commentaires:

This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur CCR7

Antigène: CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))

Autre désignation: CCR7

Sujet: EBI1, EBV-induced G-protein coupled receptor 1, Epstein-Barr virus-induced G-protein coupled receptor 1, MIP-3 beta receptor, CD197, C-C CKR-7, CC-CKR-7, C-C chemokine receptor type 7

UniProt: P47774

Pathways: Regulation of Actin Filament Polymerization, Positive Regulation of Immune Effector Process