CYB561 anticorps

N° du produit ABIN7073661

L’anticorps Lapin Polyclonal anti-CYB561 a été validé pour IF et IHC. Il convient pour détecter CYB561 dans des échantillons de Rat.

Aperçu rapide pour CYB561 anticorps (ABIN7073661)

Antigène: CYB561 (Cytochrome B-561 (CYB561))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CYB561 est non-conjugé

Application: Immunofluorescence (IF), Immunohistochemistry (IHC)

Détail du produit anti-CYB561 anticorps

Réactivité croisée: Rat

Purification: Affinity purification

Immunogène: Recombinant protein corresponding to Mouse Pyruvate Dehydrogenase E2

Information d'application

Indications d'application: IHC/IF (R) 1:500-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur CYB561

Antigène: CYB561 (Cytochrome B-561 (CYB561))

Autre désignation: Pyruvate Dehydrogenase E2

Sujet: This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95 % of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure.

ID gène: 235339

UniProt: Q8BMF4