MPL anticorps

N° du produit ABIN7074718

Détail du produit anti-MPL anticorps

Antigène: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MPL est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Rat

Purification: Affinity purification

Immunogène: KLH conjugated Synthetic peptide corresponding to Mouse TPOR

Information d'application

Indications d'application: IHC/IF (M,R) 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur MPL

Antigène: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Autre désignation: TPOR/MPL (MPL Produits)

Synonymes: anticorps C-MPL, anticorps CD110, anticorps MPLV, anticorps THCYT2, anticorps TPOR, anticorps TPO-R, anticorps c-mpl, anticorps c-mpl-I, anticorps c-mpl-II, anticorps hlb219, anticorps MPL, anticorps mpll, anticorps tpor, anticorps tpor.b, anticorps MPL proto-oncogene, thrombopoietin receptor, anticorps myeloproliferative leukemia virus oncogene, anticorps MPL, anticorps Mpl, anticorps mpl

Sujet: The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

ID gène: 17480

NCBI Accession: NP_001116421

UniProt: Q08351

Pathways: Signalistation JAK/STAT