p130 anticorps

N° du produit ABIN7075406

Cet anticorps Lapin Polyclonal détecte spécifiquement p130 dans IF et IHC. Il présente une réactivité envers Rat et Souris.

Aperçu rapide pour p130 anticorps (ABIN7075406)

Antigène: p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp p130 est non-conjugé

Application: Immunofluorescence (IF), Immunohistochemistry (IHC)

Détail du produit anti-p130 anticorps

Réactivité croisée: Rat

Purification: Affinity purification

Immunogène: Recombinant protein corresponding to Mouse Rb2 p130

Information d'application

Indications d'application: IHC/IF (M,R) 1:500-1:1500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur p130

Antigène: p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))

Autre désignation: Rb2 p130

Sujet: RBL2 (also known as p130) or Retinoblastoma-like protein 2 is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and (in particular) that of constitutive heterochromatin by stabilizing histone methylation. RBL2 recruits and targets histone methyltransferases KMT5B and KMT5C leading to epigenetic transcriptional repression. It controls histone H4 'Lys20' trimethylation. It probably also acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. RBL2 serves as a potent inhibitor of E2F-mediated trans-activation and associates preferentially with E2F5.

ID gène: 19651

NCBI Accession: NP_001268929

UniProt: Q64700

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases