TCF7 anticorps
Aperçu rapide pour TCF7 anticorps (ABIN7075952)
Antigène
Voir toutes TCF7 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Réactivité croisée
- Rat
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Purification
- Affinity purification
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Immunogène
- Recombinant protein corresponding to Mouse TCF7
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Indications d'application
- IHC/IF (M,R) 1:600-1:1200/1:600-1:1200
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- PBS, pH 7.4, 0.02 % sodium azide
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- -20 °C
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- TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7))
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Autre désignation
- TCF7
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Sujet
- TCF7 (transcriptional factor 7) is a transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ and CD8+ immature thymocytes. Isoforms for TCF7 lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. TCF7 binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. It may also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3, and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
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ID gène
- 21414
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NCBI Accession
- NP_001300910
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UniProt
- Q00417
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Pathways
- Signalisation WNT
Antigène
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