EPAS1 anticorps (AA 471-570) (Biotin)

N° du produit ABIN7091057

Cet anticorps anti-EPAS1 est un anticorps Lapin Polyclonal détectant EPAS1 dans ELISA et IHC (p). Adapté pour Rat.

Aperçu rapide pour EPAS1 anticorps (AA 471-570) (Biotin) (ABIN7091057)

Antigène: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPAS1 est conjugé à/à la Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-EPAS1 anticorps (Biotin)

Épitope: AA 471-570

Réactivité croisée: Rat

Homologie: Human,Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human HIF 2 alpha

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur EPAS1

Antigène: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Autre désignation: HIF 2 alpha

Sujet:

Synonyms: Basic helix loop helix PAS protein MOP2, Basic-helix-loop-helix-PAS protein MOP2, bHLHe73, Class E basic helix-loop-helix protein 73, ECYT4, Endothelial PAS domain containing protein 1, Endothelial pas domain protein 1, Endothelial PAS domain-containing protein 1, EPAS 1, EPAS-1, EPAS1, EPAS1_HUMAN, HIF 1 alpha like factor, HIF 2 alpha, HIF-1-alpha-like factor, HIF-2-alpha, HIF2-alpha, HIF2A, HLF, Hypoxia inducible factor 2 alpha, Hypoxia inducible factor 2 alpha subunit, Hypoxia-inducible factor 2-alpha, Member of PAS protein 2, Member of pas superfamily 2, MOP 2, MOP2, PAS domain-containing protein 2, PASD2.

Background: Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.

ID gène: 2034

UniProt: Q99814

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2, L'effet Warburg