ITGA4 anticorps (Biotin)

N° du produit ABIN7091258

Cet anticorps anti-ITGA4 est un anticorps Lapin Polyclonal détectant ITGA4 dans WB. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour ITGA4 anticorps (Biotin) (ABIN7091258)

Antigène: ITGA4 (Integrin alpha 4 (ITGA4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ITGA4 est conjugé à/à la Biotin

Application: Western Blotting (WB)

Détail du produit anti-ITGA4 anticorps (Biotin)

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Integrin alpha 4

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000

Restrictions: For Research Use only

Stockage

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur ITGA4

Antigène: ITGA4 (Integrin alpha 4 (ITGA4))

Autre désignation: Integrin alpha 4

Sujet:

Synonyms: Alpha 4 subunit of VLA 4 receptor,ITG-_4: Antigen CD49D, CD 49d , CD49d, CD49d antigen, CDw49d, IA4, Integrin alpha IV, ITGA 4, ITGA4, LPAM23, MGC90518, Very Late Activation Antigen 4, Very Late Activation Protein 4 Receptor Alpha 4 Subunit, VLA 4, VLA4, integrin alpha-4, ITA4_HUMAN,

Background: Integrin alpha 4 (also called CD49d) is a 150 kDa protein that possesses a large extracellular domain involved in ligand binding, a single transmembrane domain, and an intracellular regulatory domain possessing multiple sites for phosphorylation. Integrin alpha 4 forms heterodimers with integrins beta 1 and beta 7. Integrin alpha 4 is expressed on leukocytes and leukocyte precursors, neural crest cells, and developing skeletal muscles and is essential for embryogenesis, hematopoiesis, and immune responses. The presence of integrin alpha 4 promotes cell migration and inhibits cell spreading and contractility. Integrin alpha 4 function has been implicated in the pathogenesis of multiple diseases including asthma, rheumatoid arthritis, Crohn's disease, ulcerative colitis, hepatitis C, and multiple sclerosis, and therefore, modulation of integrin alpha 4 function has become an important target for drug discovery.

ID gène: 3676

UniProt: P13612

Pathways: Integrin Complex