Integrin beta 3 anticorps (AA 251-350)

N° du produit ABIN7091267

Cet anticorps anti-Integrin beta 3 est un anticorps Lapin Polyclonal détectant Integrin beta 3 dans WB et ELISA. Adapté pour Humain et Souris.

Aperçu rapide pour Integrin beta 3 anticorps (AA 251-350) (ABIN7091267)

Antigène: Integrin beta 3 (ITGB3)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Integrin beta 3 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-Integrin beta 3 anticorps

Épitope: AA 251-350

Réactivité croisée: Humain, Souris

Homologie: Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Integrin beta 3

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000

Restrictions: For Research Use only

Stockage

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur Integrin beta 3

Antigène: Integrin beta 3 (ITGB3)

Autre désignation: Integrin beta 3

Sujet:

Synonyms: Integrin beta-3, Integrin beta chain, ??3 precursor, Integrin Beta 3, CD 61, CD61, CD61 antigen, GP3A, GPIIIa, HPA 1, HPA 4, Integrin beta 3 (platelet glycoprotein IIIa antigen CD61), Integrin beta chain beta 3, ITG B3, ITGB 3, ITGB3, NAIT, Platelet fibrinogen receptor beta subunit, Platelet glycoprotein IIIa, platelet glycoprotein IIIa precursor, Platelet membrane glycoprotein IIIa, PTP, ITB3_HUMAN.

Background: Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

ID gène: 3690

UniProt: P05106

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex