SREBF chaperone anticorps (AA 41-140)

N° du produit ABIN7091694

Cet anticorps Souris Monoclonal détecte spécifiquement SREBF chaperone dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour SREBF chaperone anticorps (AA 41-140) (ABIN7091694)

Antigène: SREBF chaperone (SCAP)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SREBF chaperone est non-conjugé

Application: Western Blotting (WB)

Clone: B7T5

Détail du produit anti-SREBF chaperone anticorps

Épitope: AA 41-140

Homologie: Human

Immunogène: KLH conjugated synthetic peptide derived from human SCAP

Information d'application

Indications d'application: WB 1:300-5000

Restrictions: For Research Use only

Stockage

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur SREBF chaperone

Antigène: SREBF chaperone (SCAP)

Autre désignation: SCAP

Sujet:

Synonyms: KIAA0199, SCAP_HUMAN, SREBF chaperone, SREBF chaperone protein, SREBP cleavage activating protein, SREBP cleavage-activating protein, Sterol regulatory element binding protein cleavage-activating protein, Sterol regulatory element-binding protein cleavage-activating protein.

Background: Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway.

ID gène: 22937

UniProt: Q12770

Pathways: SARS-CoV-2 Protein Interactome