SUFUH anticorps

N° du produit ABIN7091703

Cet anticorps Souris Monoclonal détecte spécifiquement SUFUH dans WB et IHC (p). Il présente une réactivité envers Humain.

Aperçu rapide pour SUFUH anticorps (ABIN7091703)

Antigène: SUFUH (Suppressor of Fused Homolog (SUFUH))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SUFUH est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: D6S12

Détail du produit anti-SUFUH anticorps

Homologie: Human,Mouse,Monkey

Immunogène: Recombinant human SUFU.

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur SUFUH

Antigène: SUFUH (Suppressor of Fused Homolog (SUFUH))

Autre désignation: SUFU

Sujet:

Synonyms: SU FU, SU(F)U, Su(fu), SUFU_HUMAN, SUFUH, SUFUXL, Suppressor of fused homolog (Drosophila), Suppressor of fused homolog, OTTHUMP00000020374, OTTHUMP00000020377, OTTHUMP00000020379, PRO1280.

Background: Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).

ID gène: 51684

UniProt: Q9UMX1

Pathways: Signalisation Hedgehog, Tube Formation, Maintenance of Protein Location