Adenylosuccinate Lyase anticorps

N° du produit ABIN7111349

L’anticorps Lapin Polyclonal anti-Adenylosuccinate Lyase a été validé pour WB, IHC, ELISA, IF et FACS. Il convient pour détecter Adenylosuccinate Lyase dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Adenylosuccinate Lyase anticorps (ABIN7111349)

Antigène: Adenylosuccinate Lyase (ADSL)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Adenylosuccinate Lyase est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-Adenylosuccinate Lyase anticorps

Fonction: ADSL antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: adenylosuccinate lyase

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:5000, IHC: 1:20-1:200, IF: 1:10-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur Adenylosuccinate Lyase

Antigène: Adenylosuccinate Lyase (ADSL)

Autre désignation: ADSL

Sujet:

Synonyms: Adenylosuccinate lyase (ADSL, ASL)|Adenylosuccinase (ASase)|ADSL|AMPS

Background: ADSL(adenylosuccinate lyase) is also named as AMPS, ASase, ASL and belongs to the lyase 1 family. It is an enzyme involved in 2 pathways of purine nucleotide metabolism and catalyzes cleavage of succinyl groups to yield fumarate(PMID:18524658). Defects in ADSL are the cause of adenylosuccinase deficiency(ADSL deficiency). In humans, mutations in ADSL lead to an inborn error of metabolism originally characterized by developmental delay, often with autistic features(PMID:20884265)..The ADSL enzymatic activity is reduced in lymphocytes and red blood cells of the patient with severe psychomotor retardation(PMID:9545543). It has 2 isoforms produced by alternative splicing.

Poids moléculaire: 55 kDa

ID gène: 158

UniProt: P30566

Pathways: Ribonucleoside Biosynthetic Process