alpha KGDHC anticorps

N° du produit ABIN7111489

Cet anticorps Lapin Polyclonal détecte spécifiquement alpha KGDHC dans WB, IHC, ELISA et IF. Il présente une réactivité envers Humain, Rat et Souris.

Aperçu rapide pour alpha KGDHC anticorps (ABIN7111489)

Antigène: alpha KGDHC (alphaKGDHC) (alpha Ketoglutarate Dehydrogenase (alphaKGDHC))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp alpha KGDHC est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-alpha KGDHC anticorps

Fonction: OGDH antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur alpha KGDHC

Antigène: alpha KGDHC (alphaKGDHC) (alpha Ketoglutarate Dehydrogenase (alphaKGDHC))

Autre désignation: OGDH

Sujet:

Synonyms: 2-oxoglutarate dehydrogenase complex component E1 (E1o, OGDC-E1, OGDH-E1)|2-oxoglutarate dehydrogenase, mitochondrial|Alpha-ketoglutarate dehydrogenase (Alpha-KGDH-E1)|Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase|OGDH

Background: This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Poids moléculaire: 116 kDa

ID gène: 4967

UniProt: Q02218