APP anticorps (AA 1-300)

N° du produit ABIN7111534

Cet anticorps Souris Monoclonal détecte spécifiquement APP dans WB, ELISA et IHC. Il présente une réactivité envers Humain et Porc.

Aperçu rapide pour APP anticorps (AA 1-300) (ABIN7111534)

Antigène: APP (Amyloid beta (A4) Precursor Protein (APP))

Reactivité: Humain, Porc

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp APP est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Clone: 8B9

Détail du produit anti-APP anticorps

Épitope: AA 1-300

Fonction: APP antibody

Purification: Protein A+G purification

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 1-300aa

Immunogen: amyloid beta A4 precursor protein

Isotype: IgG2a

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:50-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur APP

Antigène: APP (Amyloid beta (A4) Precursor Protein (APP))

Autre désignation: APP

Sujet:

Synonyms: Amyloid-beta precursor protein (APP)|ABPP|APPI|Alzheimer disease amyloid A4 protein homolog|Alzheimer disease amyloid protein|Amyloid precursor protein|Amyloid-beta (A4) precursor protein|Amyloid-beta A4 protein|Cerebral vascular amyloid peptide (CVAP)|PreA4|Protease nexin-II (PN-II)|N-APP|Soluble APP-alpha (S-APP-alpha)|Soluble APP-beta (S-APP-beta)|C99 Alternative names: Beta-secretase C-terminal fragment (Beta-CTF)|Amyloid-beta protein 42 (Abeta42) Alternative names: Beta-APP42|Amyloid-beta protein 40 (Abeta40) Alternative names: Beta-APP40|C83 Alternative names: Alpha-secretase C-terminal fragment (Alpha-CTF)|P3(42)|P3(40)|C80|Gamma-secretase C-terminal fragment 59 Alternative names: Amyloid intracellular domain 59 (AICD-59, AID(59))|Gamma-CTF(59)|Gamma-secretase C-terminal fragment 57 Alternative names: Amyloid intracellular domain 57 (AICD-57, AID(57))|Gamma-CTF(57)|Gamma-secretase C-terminal fragment 50 Alternative names: Amyloid intracellular domain 50 (AICD-50, AID(50))|Gamma-CTF(50)|C31|APP|A4|AD1

Background: Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Beta-amyloid 42 is a more effective reductant than beta-amyloid 40. Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts. The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.

Poids moléculaire: 100 kDa

ID gène: 351

UniProt: P05067

Pathways: Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour