BBS1 anticorps

N° du produit ABIN7111930

Cet anticorps Lapin Polyclonal détecte spécifiquement BBS1 dans ELISA, WB, IHC, IF et IP. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour BBS1 anticorps (ABIN7111930)

Antigène: BBS1 (Bardet-Biedl Syndrome 1 (BBS1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BBS1 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Détail du produit anti-BBS1 anticorps

Fonction: BBS1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: Bardet-Biedl syndrome 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:1000, IHC: 1:50-1:200 IP: 1:500-1:1000, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur BBS1

Antigène: BBS1 (Bardet-Biedl Syndrome 1 (BBS1))

Autre désignation: BBS1

Sujet:

Synonyms: Bardet-Biedl syndrome 1 protein|BBS2-like protein 2|BBS1|BBS2L2

Background: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor(GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog(SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.

Poids moléculaire: 65 kDa

ID gène: 582

UniProt: Q8NFJ9

Pathways: Signalisation Hedgehog