BBS5 anticorps (AA 1-341)

N° du produit ABIN7111936

Cet anticorps Souris Monoclonal détecte spécifiquement BBS5 dans WB, ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour BBS5 anticorps (AA 1-341) (ABIN7111936)

Antigène: BBS5 (Bardet-Biedl Syndrome 5 (BBS5))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BBS5 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Clone: 7E11

Détail du produit anti-BBS5 anticorps

Épitope: AA 1-341

Fonction: BBS5 antibody

Purification: Protein A+G purification

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 1-341aa

Immunogen: Bardet-Biedl syndrome 5

Isotype: IgG2a

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:50-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur BBS5

Antigène: BBS5 (Bardet-Biedl Syndrome 5 (BBS5))

Autre désignation: BBS5

Sujet:

Synonyms: Bardet-Biedl syndrome 5 protein|BBS5

Background: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor(GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog(SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.

Poids moléculaire: 40 kDa

ID gène: 129880

UniProt: Q8N3I7

Pathways: Signalisation Hedgehog