BCL2L1 anticorps (AA 1-233)

N° du produit ABIN7111964

L’anticorps Souris Monoclonal anti-BCL2L1 a été validé pour WB, IHC, ELISA et IF. Il convient pour détecter BCL2L1 dans des échantillons de Humain.

Aperçu rapide pour BCL2L1 anticorps (AA 1-233) (ABIN7111964)

Antigène: BCL2L1 (BCL2-Like 1 (BCL2L1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BCL2L1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Clone: 2A9

Détail du produit anti-BCL2L1 anticorps

Épitope: AA 1-233

Fonction: BCL2L1 antibody

Purification: Protein A+G purification

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 1-233aa

Immunogen: BCL2-like 1

Isotype: IgG2a

Information d'application

Indications d'application: WB: 1:2000-1:20000, IHC: 1:200-1:600, IF: 1:10-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur BCL2L1

Antigène: BCL2L1 (BCL2-Like 1 (BCL2L1))

Autre désignation: BCL2L1

Sujet:

Synonyms: Bcl-2-like protein 1 (Bcl2-L-1)|Apoptosis regulator Bcl-X|BCL2L1|BCL2L|BCLX

Background: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel(VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release(PubMed:17418785). Isoform Bcl-X(S) promotes apoptosis.

Poids moléculaire: 35 kDa

ID gène: 598

UniProt: Q07817

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling