BRD8 anticorps (AA 530-920)

N° du produit ABIN7112079

Cet anticorps anti-BRD8 est un anticorps Souris Monoclonal détectant BRD8 dans WB, ELISA, IHC et IF. Adapté pour Humain.

Aperçu rapide pour BRD8 anticorps (AA 530-920) (ABIN7112079)

Antigène: BRD8 (Bromodomain Containing 8 (BRD8))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BRD8 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: 4B2

Détail du produit anti-BRD8 anticorps

Épitope: AA 530-920

Fonction: BRD8 antibody

Purification: Protein A+G purification

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 530-920aa

Immunogen: bromodomain containing 8

Isotype: IgG1

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:50-1:500, IF: 1:50-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur BRD8

Antigène: BRD8 (Bromodomain Containing 8 (BRD8))

Autre désignation: BRD8

Sujet:

Synonyms: Bromodomain-containing protein 8|Skeletal muscle abundant protein|Skeletal muscle abundant protein 2|Thyroid hormone receptor coactivating protein of 120 kDa (TrCP120)|p120|BRD8|SMAP|SMAP2

Background: May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors(NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase(HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Poids moléculaire: 120 kDa

ID gène: 10902

UniProt: Q9H0E9