CTNNA1 anticorps (AA 200-536)

N° du produit ABIN7112383

Cet anticorps Souris Monoclonal détecte spécifiquement CTNNA1 dans WB, IHC et ELISA. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour CTNNA1 anticorps (AA 200-536) (ABIN7112383)

Antigène: CTNNA1 (Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CTNNA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 0A11

Détail du produit anti-CTNNA1 anticorps

Épitope: AA 200-536

Fonction: CTNNA1 antibody

Purification: Protein A+G purification

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 200-536aa

Immunogen: catenin(cadherin-associated protein), alpha 1, 102kDa

Isotype: IgG1

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:50-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur CTNNA1

Antigène: CTNNA1 (Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1))

Autre désignation: CTNNA1

Sujet:

Synonyms: Catenin alpha-1|Alpha E-catenin|Cadherin-associated protein|Renal carcinoma antigen NY-REN-13|CTNNA1

Background: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E-and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

Poids moléculaire: 95-100 kDa

ID gène: 1495

UniProt: P35221

Pathways: Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Maintenance of Protein Location