CNOT1 anticorps

N° du produit ABIN7112432

L’anticorps Lapin Polyclonal anti-CNOT1 a été validé pour ELISA, WB, IHC et IP. Il convient pour détecter CNOT1 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour CNOT1 anticorps (ABIN7112432)

Antigène: CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CNOT1 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Détail du produit anti-CNOT1 anticorps

Fonction: CNOT1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: CCR4-NOT transcription complex, subunit 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur CNOT1

Antigène: CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))

Autre désignation: CNOT1

Sujet:

Synonyms: CCR4-NOT transcription complex subunit 1|CCR4-associated factor 1|Negative regulator of transcription subunit 1 homolog (NOT1H, hNOT1)|CNOT1|CDC39|KIAA1007|NOT1

Background: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element(ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem(ES) cell identity.

Poids moléculaire: 240-250 kDa, 174 kDa

ID gène: 23019

UniProt: A5YKK6

Pathways: Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Stem Cell Maintenance