CHMP2A anticorps

N° du produit ABIN7112645

L’anticorps Lapin Polyclonal anti-CHMP2A a été validé pour WB et ELISA. Il convient pour détecter CHMP2A dans des échantillons de Humain, Rat et Souris.

Aperçu rapide pour CHMP2A anticorps (ABIN7112645)

Antigène: CHMP2A (Charged Multivesicular Body Protein 2A (CHMP2A))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHMP2A est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-CHMP2A anticorps

Fonction: CHMP2A antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: chromatin modifying protein 2A

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur CHMP2A

Antigène: CHMP2A (Charged Multivesicular Body Protein 2A (CHMP2A))

Autre désignation: CHMP2A

Sujet:

Synonyms: Charged multivesicular body protein 2a|Chromatin-modifying protein 2a (CHMP2a)|Putative breast adenocarcinoma marker BC-2|Vacuolar protein sorting-associated protein 2-1 (Vps2-1, hVps2-1)|CHMP2A|BC2|CHMP2

Background: Probable core component of the endosomal sorting required for transport complex III(ESCRT-III) which is involved in multivesicular bodies(MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O,-I,-II and-III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis(PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase(PubMed:26040712). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. (Microbial infection) The ESCRT machinery functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses(HIV-1 and other lentiviruses). Involved in HIV-1 p6-and p9-dependent virus release.

Poids moléculaire: 32 kDa

ID gène: 27243

UniProt: O43633

Pathways: SARS-CoV-2 Protein Interactome