Claspin anticorps

N° du produit ABIN7112861

L’anticorps anti-Claspin Polyclonal produit chez le Lapin a été validé pour WB, ELISA, IP et IF. Il convient pour la détection de Claspin dans des échantillons provenant de Humain. }

Aperçu rapide pour Claspin anticorps (ABIN7112861)

Antigène: Claspin (CLSPN)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Claspin est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)

Détail du produit anti-Claspin anticorps

Fonction: CLSPN antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: claspin homolog(Xenopus laevis)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:1000, IP: 1:500-1:2000, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur Claspin

Antigène: Claspin (CLSPN)

Autre désignation: CLSPN

Sujet:

Synonyms: Claspin (hClaspin)|CLSPN

Background: Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex(pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.

Poids moléculaire: 240 kDa

ID gène: 63967

UniProt: Q9HAW4