COPS4 anticorps

N° du produit ABIN7113044

L’anticorps Lapin Polyclonal anti-COPS4 a été validé pour WB, ELISA, IHC et IP. Il convient pour détecter COPS4 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour COPS4 anticorps (ABIN7113044)

Antigène: COPS4 (COP9 Signalosome Subunit 4 (COPS4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COPS4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Détail du produit anti-COPS4 anticorps

Fonction: COPS4 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: COP9 constitutive photomorphogenic homolog subunit 4(Arabidopsis)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur COPS4

Antigène: COPS4 (COP9 Signalosome Subunit 4 (COPS4))

Autre désignation: COPS4

Sujet:

Synonyms: COP9 signalosome complex subunit 4 (SGN4, Signalosome subunit 4)|JAB1-containing signalosome subunit 4|COPS4|CSN4

Background: Component of the COP9 signalosome complex(CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin(Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Poids moléculaire: 40,46 kDa

ID gène: 51138

UniProt: Q9BT78

Pathways: Cycle Cellulaire