DCLRE1B anticorps

N° du produit ABIN7113546

Cet anticorps anti-DCLRE1B est un anticorps Lapin Polyclonal détectant DCLRE1B dans WB et ELISA. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour DCLRE1B anticorps (ABIN7113546)

Antigène: DCLRE1B (DNA Cross-Link Repair 1B (DCLRE1B))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DCLRE1B est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-DCLRE1B anticorps

Fonction: DCLRE1B antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: DNA cross-link repair 1B(PSO2 homolog, S. cerevisiae)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur DCLRE1B

Antigène: DCLRE1B (DNA Cross-Link Repair 1B (DCLRE1B))

Autre désignation: DCLRE1B

Sujet:

Synonyms: 5' exonuclease Apollo|Beta-lactamase DCLRE1B|DNA cross-link repair 1B protein|SNM1 homolog B (SNMIB, hSNM1B)|DCLRE1B|SNM1B

Background: 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining(NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop(T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase(TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links(ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.

Poids moléculaire: 60 kDa

ID gène: 64858

UniProt: Q9H816