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E2F8 anticorps

E2F8 Reactivité: Humain, Souris, Rat WB, ELISA, IP Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7113688
  • Antigène Voir toutes E2F8 Anticorps
    E2F8 (E2F Transcription Factor 8 (E2F8))
    Reactivité
    • 33
    • 19
    • 18
    • 12
    • 11
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 30
    • 2
    • 1
    Lapin
    Clonalité
    • 31
    • 2
    Polyclonal
    Conjugué
    • 17
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp E2F8 est non-conjugé
    Application
    • 15
    • 12
    • 6
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunoprecipitation (IP)
    Purification
    Immunogen affinity purified
    Pureté
    ≥95 % as determined by SDS-PAGE
    Immunogène
    E2F transcription factor 8
    Isotype
    IgG
    Top Product
    Discover our top product E2F8 Anticorps primaire
  • Indications d'application
    WB: 1:500-1:2000, IP: 1:200-1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Date de péremption
    12 months
  • Antigène
    E2F8 (E2F Transcription Factor 8 (E2F8))
    Autre désignation
    E2F8 (E2F8 Produits)
    Synonymes
    anticorps MGC130750, anticorps E2F8, anticorps E2F-8, anticorps RGD1308091, anticorps 4432406C08Rik, anticorps AA410048, anticorps E2F transcription factor 8, anticorps E2F transcription factor 8 L homeolog, anticorps E2F8, anticorps e2f8.L, anticorps e2f8, anticorps E2f8
    Sujet
    Synonyms: Background:Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins(E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.
    Poids moléculaire
    82 kDa, 105 kDa
    ID gène
    79733
    UniProt
    A0AVK6
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