ECD/SGT1 anticorps (AA 1-130)

N° du produit ABIN7113709

Cet anticorps Lapin Polyclonal détecte spécifiquement ECD/SGT1 dans WB, ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour ECD/SGT1 anticorps (AA 1-130) (ABIN7113709)

Antigène: ECD/SGT1 (ECD) (Ecdysoneless Homolog (ECD))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ECD/SGT1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-ECD/SGT1 anticorps

Épitope: AA 1-130

Fonction: ECD antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 1-130aa

Immunogen: ecdysoneless homolog(Drosophila)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur ECD/SGT1

Antigène: ECD/SGT1 (ECD) (Ecdysoneless Homolog (ECD))

Autre désignation: ECD

Sujet:

Synonyms: Protein ecdysoneless homolog|Human suppressor of GCR two (hSGT1)|ECD

Background: Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP(PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes(PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins(PubMed:19640839). The cell cycle-regulating function may depend on its RUVBL1-mediated association with the R2TP complex(PubMed:26711270). May play a role in regulation of pre-mRNA splicing(PubMed:24722212).

Poids moléculaire: 70-100 kDa

ID gène: 11319

UniProt: O95905

Pathways: Regulation of Carbohydrate Metabolic Process