ERI1 anticorps

N° du produit ABIN7114005

Cet anticorps anti-ERI1 est un anticorps Lapin Polyclonal détectant ERI1 dans WB, ELISA, IHC et IF. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour ERI1 anticorps (ABIN7114005)

Antigène: ERI1 (Exoribonuclease 1 (ERI1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERI1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-ERI1 anticorps

Fonction: ERI1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: exoribonuclease 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur ERI1

Antigène: ERI1 (Exoribonuclease 1 (ERI1))

Autre désignation: ERI1

Sujet:

Synonyms: 3'-5' exoribonuclease 1|3'-5' exonuclease ERI1|Eri-1 homolog|Histone mRNA 3'-end-specific exoribonuclease|Histone mRNA 3'-exonuclease 1|Protein 3'hExo (HEXO)|ERI1|3'EXO|THEX1

Background: RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs(siRNAs) in vitro, suggesting a possible role as regulator of RNA interference(RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.

Poids moléculaire: 46 kDa

ID gène: 90459

UniProt: Q8IV48